Some medicines must not be used for a long period of time. They may bring not only the needed effects, but harm general health of a person. Try to use the medicine you have been prescribed as long as recommended and in the dose adjusted individually for you.
Celebrex belongs to non-steroidal drugs with high potential to reduce inflammation and pain. It is commonly prescribed to treat arthritis, acute pain, and menstrual aches and discomforts.
Before using this drug a person should make sure it is safe for him/her. The medicine blocks the enzyme that produces prostaglandins and thus reduces pain and swelling. Ask your doctor if it is suitable for you.
Regular use of this medicine is not recommended. It should be used only in the period of acute form of condition causing pain and inflammation.
Certain groups of patients need special dose adjustments and monitoring of body organs when they are suggested to use Celebrex.
Hepatic impairment (insufficiency): patients with liver problem should receive no more than half of the normal Celebrex dose. Patients with severe hepatic problem should not use Celebrex at all.
Patients with problem of swallowing of capsules: patients who cannot swallow capsules can use the content of the capsule with water or other liquid.
Patients with a metabolism problem (poorly metabolize CYP2C9 substrates) due to genotype or previous history of inadequate reactions to CYP2C9 substrates: should receive the half of the lowest Celebrex dose.
Patients with hypersensitivity to NSAIDs: such patients should not use Celebrex. Such patients may experience increased response to Celbrex treatment and need other options.
Patients with gastrointestinal bleeding: such patients should not use Celebrex.
Celebrex mode of action
The actual mechanism of Celebrex action is not clearly understood. The medicine produces pronounced anti-inflammatory effects with analgesia. These effects are supposed to be linked to the drug’s potential to inhibit prostaglandins (naturally occurring fatty acids which regulate inflammatory mediation).
The medicine also produces antipyretic effect (lowering temperature and fever) and pain reduction. Celecoxib selectively inhibits cyclooxygenase-2 (COX-2)isoenzyme. Researches suggest that the analgesic effects of Celecoxib are mediated by the blockade of COX – 2 enzyme. The medicine does not block COX-1 enzyme and thus does not cause any gastroenterological ill-effects involved in traditional NSAIDs treatment.
When the drug choice is in question several factors are taken into consideration. It is always recommended to start with mild analgesics at the lowest effective dose.