Celebrex general information

Some medicines must not be used for a long period of time. They may bring not only the needed effects, but harm general health of a person. Try to use the medicine you have been prescribed as long as recommended and in the dose adjusted individually for you.

Celebrex belongs to non-steroidal drugs with high potential to reduce inflammation and pain. It is commonly prescribed to treat arthritis, acute pain, and menstrual aches and discomforts.

Before using this drug a person should make sure it is safe for him/her. The medicine blocks the enzyme that produces prostaglandins and thus reduces pain and swelling. Ask your doctor if it is suitable for you.

Regular use of this medicine is not recommended. It should be used only in the period of acute form of condition causing pain and inflammation.

Certain groups of patients need special dose adjustments and monitoring of body organs when they are suggested to use Celebrex.

Hepatic impairment (insufficiency): patients with liver problem should receive no more than half of the normal Celebrex dose. Patients with severe hepatic problem should not use Celebrex at all.

Patients with problem of swallowing of capsules: patients who cannot swallow capsules can use the content of the capsule with water or other liquid.

Patients with a metabolism problem (poorly metabolize CYP2C9 substrates) due to genotype or previous history of inadequate reactions to CYP2C9 substrates: should receive the half of the lowest Celebrex dose.

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Patients with hypersensitivity to NSAIDs: such patients should not use Celebrex. Such patients may experience increased response to Celbrex treatment and need other options.

Patients with gastrointestinal bleeding: such patients should not use Celebrex.

Celebrex mode of action

The actual mechanism of Celebrex action is not clearly understood. The medicine produces pronounced anti-inflammatory effects with analgesia. These effects are supposed to be linked to the drug’s potential to inhibit prostaglandins (naturally occurring fatty acids which regulate inflammatory mediation).

The medicine also produces antipyretic effect (lowering temperature and fever) and pain reduction. Celecoxib selectively inhibits cyclooxygenase-2 (COX-2)isoenzyme. Researches suggest that the analgesic effects of Celecoxib are mediated by the blockade of COX – 2 enzyme. The medicine does not block COX-1 enzyme and thus does not cause any gastroenterological ill-effects involved in traditional NSAIDs treatment.

When the drug choice is in question several factors are taken into consideration. It is always recommended to start with mild analgesics at the lowest effective dose.

Celebrex dosage

celebrexCelebrex is available in the form of capsules containing either of 50 mg, 100 mg, 200 mg and 400 mg of celecoxib.
As the medicine may cause serious heart and blood circulation effects if used for a long time, its use should be controlled and its dose should not exceed the lowest effective one.
For the treatment of osteoarthritis and rheumatoid arthritis it is recommended to use 200 mg of Celebrex once a day or in divided doses.
For the healing of juvenile rheumatoid arthritis and pain relief in children the dose of Celebrex is chosen in accordance with a body weight of a patient. Children whose body weight is from 10 kg to 25 kg should receive 50 mg of Celebrex two times a day. Children who weigh more than 25 mg can receive 100 mg two times a day.
For the treatment of ankylosing spondylitis, the dose of 200 mg is most effective. The dose should be used once a day or in divided doses two times a day. Patients with ankylosing spondylitis may need larger doses up to 400 mg  per day to relief the symptoms of this condition.
In the treatment of dysmenorrhea and for pain relief the dose of 400 mg as initial is usually effective. In the following days of treatment the dose of 200 mg should be used.

Celebrex – a directive medicine to reduce pain

celebrexCelebrex (celecoxib) is a nonsteroidal anti-inflammatory drug indicated to reduce pain and inflammation in the body. The hormones causing discomfort, pain and swelling are inhibited by celecoxib. The medicine is available in the capsules containing 50 mg, 100 mg, 200 mg or 400 mg of celecoxib.
Celebrex is effective in the treatment of pain or inflammation caused by arthritis, ankylosing spondylitis, hereditary polyps in the colon and menstrual pain.
For the relief of pain and other symptoms of the following conditions, Celebrex is prescribed in the lowest effective dose:
•    Osteoarthritis
•    Rheumatoid Arthritis
•    Juvenile Rheumatoid Arthritis
•    Ankylosing Spondylitis
•    Acute Pain
•    Primary Dysmenorrhea
Before using Celebrex a person should get assured that the medicine is safe for health.

My opinion

iCAZCNJHEMy doctor recommended Celebrex by me, when I came to visit and said about my wrist and hand pain. But I had several side effects: in the night  I awoke with had the chills,an extremely bad headache, runny nose, aching muscles, a dry hacking cough. After I took the 2nd pill of 200 mg, I  I stopped taking Celebrex, but as my side effects persisted, I thought that it was the flu. 3 weeks later, I again tried the pills of it and on the 2nd day of taking Celebrex, I was again stricken with a headache,chills,the runny nose and nausea.

Before taking

Don’t start to use Celebrex  if you have a history of allergy to sulfa drugs, aspirin, or other NSAIDs, or if you have allergy to celecoxib.

If you have the follow condition visit to a doctor and tell him about this:

  •   congestive heart failure, high blood pressure;
  •   polyps in your nose; or
  •   asthma;
  •   heart disease,
  •   kidney or liver disease,
  •   blood clot, heart attack;
  •   a bleeding .
  •   blood clotting disorder;
  •   a history of  bleeding or stomach ulcers;
  •   a history of  stroke,
  •   a seizure disorder: epilepsy;

This drug may cause circulation problems or life-threatening heart problems: stroke or heart attack.

Do not use this drug  just after or before CABG or  coronary artery bypass graft (heart bypass surgery ).

Celebrex  may also cause serious effects on the intestines or stomach,such as  perforation  or bleeding.